Department of Research & Evaluation News

PASADENA, Calif. – High body weight in children and adolescents is strongly associated with the likelihood of hypertension, according to a Kaiser Permanente Southern California study published today in The Journal of Clinical Hypertension. 

Researchers found that young people who are overweight are twice as likely as their normal-weight peers to have hypertension; moderately obese youths have four times higher risk; and extremely obese children and adolescents are 10 times more likely to have hypertension. The study also found 10 percent of youths who are extremely obese have hypertension and nearly half have occasional blood pressure measurements in the hypertensive range. Earlier studies showed that between 1 to 5 percent of youth have hypertension.

This study’s findings suggest that pediatricians need to be particularly vigilant about screening overweight and obese children for hypertension because high blood pressure can be asymptomatic for many years, said Corinna Koebnick, PhD, lead author and researcher at Kaiser Permanente Southern California’s Department of Research & Evaluation. 

Researchers examined the electronic health records of nearly 250,000 children aged 6 to 17 years who were enrolled in Kaiser Permanente in Southern California between January 1, 2007 and December 31, 2009. The study used the first four consecutive blood pressures measured routinely as a part of clinical care during the 36-month time period. 

High blood pressure in children is a serious health condition that can lead to heart and kidney disease, said researcher David Cuan, MD, Department of Pediatrics, Kaiser Permanente Riverside Medical Center. While it is generally recommended that pediatricians measure blood pressure in children three years and older at every health care visit, this study shows the importance of screening overweight and obese young people in particular as they have an increased likelihood of hypertension.

The present results also suggest that the currently used classifications for overweight and obesity in children may be an effective tool for identifying children at high risk for hypertension. For this study, researchers used sex-specific BMI-for-age growth charts developed by the Centers for Disease Control and Prevention combined with the World Health Organization definitions for overweight and obesity in adults. Being above the threshold for overweight was an indicator for prehypertension, while being above the threshold for obesity was an indicator for hypertension. 

This study highlights a great use of existing high-quality data for addressing important scientific questions, in this case, the challenge of screening asymptomatic children for hypertension, said Matthew F. Daley, MD, a pediatrician and a researcher at the Institute for Health Research, Kaiser Permanente Colorado. The findings of this study suggest that we should focus our limited resources on the children who need the most timely follow up. 

Kaiser Permanente can conduct transformational health research like this in part because it has the largest private patient-centered electronic health record system in the world. The organization’s electronic health record system, Kaiser Permanente HealthConnect®, securely connects 9.1 million patients to 17,000 physicians in 611 medical offices and 37 hospitals. It also connects Kaiser Permanente’s research scientists to one of the most extensive collections of longitudinal medical data available, facilitating studies and important medical discoveries that shape the future of health care delivery for patients and the medical community. 

This research was supported by the National Institute of Diabetes and Digestive and Kidney Disorders under award numbers NIDDK, R21DK085395. 

Other authors on the study include Mary Helen Black, PhD, Jun Wu, MD, MS, Mayra P. Martinez, MPH, Ning Smith, PhD, Deborah Rohm Young, PhD, Jean M. Lawrence, ScD, MPH, MSSA, and Steven J. Jacobsen, MD, PhD, of the Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, Calif.; Beatriz Kuizon, MD, Pediatric Nephrology, Kaiser Permanente Los Angeles Medical Center; and David Cuan, MD, Department of Pediatrics, Kaiser Permanente Riverside Medical Center, Riverside, CA.

About the Kaiser Permanente Department of Research & Evaluation 

The Department of Research & Evaluation conducts high-quality, innovative research into disease etiology, prevention, treatment and care delivery. Investigators conduct epidemiology, health sciences and behavioral research, as well as clinical trials. Areas of interest include diabetes and obesity, cancer, HIV/AIDS, cardiovascular disease, aging and cognition, pregnancy outcomes, women’s and children’s health, quality and safety and pharmacoepidemiology. Located in Pasadena, Calif., the department focuses on translating research to practice quickly to benefit the health and lives of Kaiser Permanente Southern California members and the general population. Visit kp.org/research

About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America’s leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve more than 9.1 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the-art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to share.kp.org