RESEARCH

The primary goal of the network is to modernize diabetes surveillance efforts to capitalize on large-volume, electronic health record data streams to provide accurate, timely, cost-effective, granular, and representative indicators of diabetes prevalence and incidence. We aim to monitor overall trends and trends within subgroups (e.g., age, sex, diabetes type, and geographic area).

The major goal of this project is to develop approaches that can arrest or reverse progressive Beta-cell disease.

KPSC is one of nine sites throughout the country funded by an Innovation Award from the Centers of Medicare and Medicaid to implement a coordinated care model for depressed patients with cardiovascular disease. We have the following goals for this project: 1. To implement in three stages a multiple condition collaborative care management model in primary care clinics of care systems in states. 2. To demonstrate that this model improves care quality, patient experience and health, provider satisfaction, and total healthcare costs for the Medicare and Medicaid patients with the targeted conditions. 3. To develop role descriptions and training for the two new types of workers required for this model – care managers and care consultants. 4. To identify the costs and payment models needed by care systems to sustain and spread this care model.

The primary goal of this study is to assess the impact of specific glucose-lowering strategies on cardiovascular events and on mortality in order to identify whether some glucose-lowering strategies confer more cardiovascular benefit than others.

This application is proposed to call back ~400 individuals in our previous cross-sectional BetaGene cohort study (NIDDK 61628) and re-test them for phenotypes. Analysis will be conducted to determine which genes and how they interact with each other to impact the longitudinal changes in beta-cell function and other T2DM related traits.

The overall goal of this study is to identify the associations of the in-utero cardio-metabolic milieu with young adult cardiovascular health and subclinical cardiovascular disease in offspring, and to investigate whether DNA methylation mediates these associations.

This study uses electronic health records to determine the effects of sugary beverage taxes initiated in 4 Northern California cities compared with control cities in Northern and Southern California. Outcomes include weight change trajectories and prevalence of overweight and obesity among children and adults, and incidence of diabetes among adults with prediabetes. Pre-specified sub-analyses include examining differences by race/ethnicity, age groups, and neighborhood socioeconomic status.

The over-arching goal of this study is to assess the physiologic effect of genetic variation in humans and determine how variation in genes alters physiologic processes to contribute to diabetes pathogenesis.

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

To determine the feasibility of a primary care based, telephone counseling physical activity behavioral intervention for diabetics and prediabetics.

EPPC is testing the effects of a 2-year motivational interview, telephone-based intervention on increasing moderate to vigorous physical activity among participants with diabetes and prediabetes.

The goal of this study is to examine the long-term development of complications over the course of type 2 diabetes and estimate the incidence of complications including cardiovascular disease, chronic kidney disease, end-stage renal disease, neuropathy, diabetic retinopathy to inform strategies to reduce the burden of type 2 diabetes complications.

The overall goal of this non-interventional study is to analyze the economic impact of triglyceride lowering and to determine whether this differs among patients who did and did not receive therapy to intentionally lower triglycerides.

This project measured a large panel of pro- and anti-inflammatory adipokines in existing blood samples collected from BetaGene I and II study participants, combine these data with genome-wide genetic variation, dietary and physical activity information, and elucidate the pathophysiological pathways that underlie metabolic decline leading to type 2 diabetes.