RESEARCH

The goal of this study is to examine the association between chronic co-morbid conditions and risk of febrile neutropenia, and grade III and IV neutropenia associated with first cycle chemotherapy.

This is an award to demonstrate the feasibility of developing a registry of individuals who undergo lung cancer screening with low-dose CT.

This study is to investigate disparities by HIV status and modifiable risk factors for delays in cancer treatment initiation, treatment completion, and short- and long-term adverse events for persons with HIV (PWH) who were members of the Veteran’s Administration or Kaiser Permanente, the two largest healthcare systems in the United States. Study findings will provide necessary data to inform HIV-specific cancer treatment guidelines and improve cancer care delivery and outcomes for PWH.

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and although the overall CRC mortality rate has been decreasing, disparities have persisted, particularly for Black and Native American people. The goal of this study is to inform feasible and effective strategies for advancing health equity by elucidating the extent to which differences in care along the entire screening process cumulatively contribute to disparities. We will comprehensively evaluate the entire screening continuum from the tests used and screening quality to receipt of follow-up care and guideline-concordant treatment in a cohort of about 3.8 million people per year over a nearly 2-decade period in Kaiser Permanente Northern California (KPNC) and Kaiser Permanente Southern California (KPSC).

The aim of this longitudinal cohort study is to evaluate the comparative safety and risk of opioids and psychotropic drugs in women with breast cancer who suffer from chronic pain due to cancer or its treatments.

An Examination of Chronic Health Problems of Survivors of Cancer

This study examines drug interactions between tamoxifen and antidepressants in nearly 23,000 breast cancer survivors diagnosed with early stage disease in the two largest health plans in California.

The aim of this project is to examine cellular and genomic markers of inflammation, telomere erosion, telomere length, and microarray data of 300 breast cancer survivors and comparison women who are enrolled in the KPSC-UCLA collaborative STRIVE1 and STRIVE2 studies.

The major goals of the project are to evaluate the effectiveness of a web-based decision aid on improving knowledge about breast cancer screening in women age 40 to 49 and reducing decisional conflict about breast cancer screening, and to explore the acceptability and feasibility of large-scale implementation.

The aim of this cohort is to assess the risk of cardiovascular disease associated with endocrine treatments for breast cancer.

To understand real world outcomes in patients with invasive stage breast cancer who receive HER2-directed adjuvant treatment.

The goal of this observational study is to evaluate the average risk of febrile neutropenia (FN) in patients receiving chemotherapy regimens with previously undefined FN risk.

The goal of this project is to evaluate the long-term health outcomes, including mortality, second cancer and comorbidities among survivors of adolescent and young adult cancer. The magnitude of risk increase of specific late effects associated with specific cancer therapeutic exposure will also be characterized.

The aim of this investigation initiated retrospective cohort study are to examine long-term health effects in the cohort of CML and determine if health effects vary by drug adherence to TKIs.

The goals of this study are to assess pregnancy risks among female AYA cancer survivors; assess risk of adverse infant birth outcomes; and examine factors that may contribute to risk of pregnancy loss or adverse birth outcomes

The major goal of this project is to compare two implementation strategies to facilitate adoption of primary HPV testing for routine cervical cancer screening measured by patient-, provider- and system-centered outcomes. A sub-analysis and survey data collection will evaluate the impact of the COVID pandemic on this practice change and cervical cancer screening.

The goal of this mixed methods study is to develop and test interventions to reduce use of surveillance biomarkers for early stage breast cancer patients.

This study will examine the role of cruciferous vegetable intake, in conjunction with genetic polymorphisms related to ITC metabolism, in potentially reducing disease recurrence and progression, and increasing the efficacy of intravesical bladder cancer treatment.

The primary objective of this study is to estimate the resource utilization and direct medical expenditure associated with neutropenia and febrile neutropenia, in Non-Hodgkin’s Lymphoma, Breast cancer and Lung cancer patients. The secondary objective is to determine the trend of incidence of neutropenia with and without fever in Non-Hodgkin’s Lymphoma, Breast cancer and Lung cancer. The study will also describe management patterns and evaluate trend of management patterns for febrile neutropenia. Lastly, we will also estimate the febrile neutropenia specific mortality rate in hospitalized patients by cancer type.

Adolescents and young adults with cancer aged 12-39 account for more than 70,000 new cancer diagnoses in the United States per year, and cancer is their leading disease-related cause of death. This study will evaluate the current state of end-of-life care quality among adolescent and young adult patients and develop a set of quality indicators that capture adolescent and young adult values for care. This work will enable valid assessment of care quality and rigorous evaluation of interventions to improve adolescent and young adult end-of-life care delivery.

In this nested case control study, we extract and validate both common and rare symptoms of pancreatic cancer based on electronic health records (EHR) of Kaiser Permanente Southern California (KPSC). More specifically, we attempt to (1) extract from the stored information on symptoms from EHR based on structured, semi-structured and un-structured data, (2) evaluate the accuracy of such EHR information, overall and in different clinical settings, (3) report the prevalence of each symptom in cases and controls and the median time to diagnosis in cases for each specific symptom, (4) examine the association of the each symptom with PDAC status, and finally (5) make recommendations on the appropriate application of the electronic algorithms to identify symptoms for future studies related to pancreatic cancer.

This project aims to evaluate adherence to Children’s Oncology Group Long-Term Follow-up Guidelines and population preventive care guidelines among survivors of adolescent and young adult (AYA) cancer.

Dr. Haque was awarded travel funds to attend conferences related to hereditary cancers.

The goal of this project is to develop DNA methylation marker-based prediction algorithms that will assist clinicians when providing therapeutic recommendations for men with localized prostate cancer.

The goal of this project is to estimate the impact of bariatric surgery versus routine non-surgical care on the incidence of cancer (all types) in all severely obese patients (men and women).

In the Be-Well Study of 1,472 non-muscle invasive bladder cancer (NMIBC) survivors, we propose to conduct a comprehensive investigation of body composition and the immune/inflammatory state at the time of cancer diagnosis and their outcomes at eight years post-diagnosis.

This project focuses on implementation and effectiveness of an evidence-based guideline recommendation for systematic distress screening for breast cancer patients.

The aim of this cohort study is to examine if management of comorbidities can help mitigate the disparities seen in survival among women with metastatic breast cancer.

The specific aim of the Cancer Care Delivery Research portion of this program is to conduct and help design cancer care delivery research within the National Community Oncology Research Program (NCORP

Given the lack of evidence regarding the benefits or harms of cannabis, we will conduct a new study of 1000 adult cancer patients to compare people who use cannabis versus non-users. Our study will provide new information to educate individuals and their healthcare providers about whether to consider using cannabis alongside other conventional ways to manage cancer-related symptoms.

The goal of this study is to investigate whether the genetic variation in the human leukocyte antigen and other key a priori genes linked to human leukocyte antigen, including tumor necrosis factor play a role in non-Hodgkin lymphoma prognosis and overall survival.

The goal of this study is to examine the effectiveness of NGS testing (tissue failure rates, time to NGS results), distribution of NGS testing, and prevalence of targetable driver mutations by patient’s demographic and clinical characteristics.

This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.

The goal is to assess fatal and morbid outcomes up to 15 years following androgen deprivation therapy for men initially diagnosed with localized prostate cancer.

This study aims to explore rational combination therapies aimed at cytoreduction of advanced tumors followed by antibody-mediated immune checkpoint inhibition to stimulate adaptive T cell anti-lymphoma immunity. We will study a large cohort of human diffuse large B cell (DLBCL) samples and utilize syngeneic, immunocompetent mouse lymphoma models that mimic the varied sensitivity of human B cell NHL to kinase inhibitors

The major goals of this project are to develop innovative risk-adaptive models of cancer surveillance for colorectal, chronic myeloid leukemia, and prostate cancer using value-of-information statistical methodology.

The goal of this study is to evaluate the feasibility of determining the occurrence of neutropenia and febrile neutropenia as well as cancer treatment using electronic medical records.

This study examines if depression and its treatment can affect the course of prostate cancer.

This project will develop a population-based approach to returning results of genetic testing for these conditions to increase detection and offer risk reducing and early screening options for patients. This project represents an important opportunity for KPSC in implementing broad population-screening.

This study aims to evaluate purported risk factors for NHL and its subtypes using a pooled analysis of>500,000 individuals from five cohort studies

The goal of this study it to evaluate patterns of medical imaging associated with cumulative exposure to radiation (CT, nuclear medicine, fluoroscopy, angiography, and radiography), and subsequent risk of childhood cancers.

The aim of this cohort study is to examine how combined breast cancer adjuvant therapies affect the risk of developing early and late cardiovascular disease. Results will be used to develop risk prediction models to inform clinical decision-making to optimize cancer control while mitigating cardiovascular disease risk.

The goal of this prospective recruitment study is to evaluate longitudinal differences in the rates of change in inflammation and telomere erosion in breast cancer survivors vs. non-cancer comparison women to determine if such molecular changes are due to cancer biology, or its treatment, or consequences of aging.

The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.

The goal of this project is to define molecular subtypes of non-muscle invasive bladder cancer using data and samples from the Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be-Well), the largest prospective cohorts of newly diagnosed bladder cancer patients, with an ultimate goal to identify molecular signatures to refine the current pathological risk stratification and inform treatment response prediction.

In a multiregional, retrospective cohort study of patients with hormone-receptor positive/HER2+ and HER2-metastatic breast cancer diagnosed from 2012-2019, we will describe sociodemographic factors, clinical characteristics, and treatment modalities and describe clinical outcomes.

The goal of this prospective recruitment study is to determine if ovarian cancer screening is enhanced by more frequent biomarker testing (CA125 & HE4) versus usual testing frequency in women with BRCA1/2 mutations.

The goal of this study is to gain insight and understanding into planned and implemented processes of survivorship care in diverse health care settings.

A retrospective analysis to evaluate the utilization of Q2W and dosing of durvalumab and impact on treatment outcomes among patients with unresectable stage III NSCLC treated within the Kaiser Permanente integrated delivery system.