Bone Health and Orthopedics studies
Clinical Biomechanics of Hip Fracture
The aim for this study is to extend biomechanical analyses of CT (BCT) to more completely incorporate all major biomechanical aspects of hip fracture etiology, using available clinical data to optimize the ability of BCT to clinically identify patients at high risk of hip fracture, particularly those who do not have BMD-defined osteoporosis or those who are at more imminent or short-term risk fracture.
Site Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Funding Years:
2020 - 2023Research Categories:
Bone Health and OrthopedicsFracture, Osteopenia, and CT Utilization Study (FOCUS Study)
The aim of this study is to validate within a population of KPSC patients the ability of a CT-based Biomechanical CT analysis to identify patients with osteopenia who are at high risk for hip fracture.
Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
Merck & Co., Inc.Funding Years:
2015 - 2017Research Categories:
Bone Health and OrthopedicsOsteoporotic fractures and associated healthcare resource utilization
The primary aim of this cohort study is to assess the downstream effects of fragility fracture, including mortality, recurrent fracture, and health-care resource utilization in the first post-fracture year.
Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
Radius Health, Inc.Funding Years:
2018 - 2020Research Categories:
Bone Health and OrthopedicsPooling International Cohort Studies of Long-Term Bisphosphonate Use and Atypical Femur Fractures
The aim of this study is to use individual-level data from three large, population-based cohorts with radiographically adjudicated atypical femur fractures (AFFs) to determine how the risk of AFFs relates to bisphosphonate treatment duration, drug holidays, and treatment re-initiation while accounting for other potential risk factors. This information will be used to develop models to predict individual AFF risk, combining clinical risk factors, patterns of long-term anti-osteoporosis treatment, and periods of drug holiday.
Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Funding Years:
2022 - 2027Pre-operative Assessment of Fusion-related Bone Failure
The objective of this case-cohort study is to apply biomechanical computed tomography (BCT) analysis and virtual stress testing (VST) to pre-operative CT scans for a cohort of candidates for spine-fusion surgery to predict clinical/surgical outcomes such as pedicle screw failure, endplate subsidence, proximal junctional failure, and overall surgery failure. We will be testing the hypothesis that VST indices can predict surgical failure independent of other known pre-operative risk factors or bone mineral density.
Site Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
National Institutes of Health (NIH)Funding Years:
2018 - 2019Research Categories:
Bone Health and OrthopedicsRetrospective Cohort Study of Risk of Hip Fractures Associated with High Dose, Long-term Proton Pump Inhibitor (HD-PPI) Use and Cytochrome P450 Pharmacogenomics
The main goals of this study are to conduct two related cohort studies intended to address questions related to the association between PPI and HD-PPI use in a setting of complex medication usage patterns and to conduct a pharmacogenetics study exploring potential modification of the relationship between PPI use and hip fracture risk by CYP2C19 genotype.
Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
Food and Drug Administration (FDA)Funding Years:
2014 - 2018Skeletal Outcomes in Primary Hyperparathyroidism
The aim of the study is to retrospectively compare fracture rates and BMD changes in patients with PHPT who have received the following types of treatment: observation, bisphosphonate therapy, surgery, or both surgery and bisphosphonate therapy.
Principal Investigator:
Annette L. Adams, PhD, MPHFunding Source:
University of California, Los Angeles (UCLA)Funding Years:
2013 - 2019Studying the relationship of hyponatremia on bone disease, fractures, and fall risk
A cross sectional and longitudinal study that seeks to establish or determine a relationship between hyponatremia and bone density disorders (osteoporosis); hyponatremia and vertebral fractures; hyponatremia and risk of hip fractures.