RESEARCH

The goals of this pilot project are to develop a chronic kidney disease (CKD) discordance index defined by the presence of chronic conditions and treatments that oppose, contradict, or complicate CKD treatment or worsen kidney function in a subsample of CKD patients from KPSC

Studies evaluating the role of hepatitis C viral (HCV) infection on the progression of CKD are few and conflicting. Therefore, we evaluated the association of untreated HCV on kidney function decline in patients with stage 3-5 CKD.

Atrial fibrillation affects ~25% of patients with kidney disease and is associated with poor clinical outcomes. It remains unknown whether standard therapies for atrial fibrillation are effective and safe in patients with chronic kidney disease. The overall goal of this proposal to study the receipt, safety and efficacy of medications and procedures used in the treatment of atrial fibrillation in patients with kidney disease.

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

The goal of this study is to examine the long-term development of complications over the course of type 2 diabetes and estimate the incidence of complications including cardiovascular disease, chronic kidney disease, end-stage renal disease, neuropathy, diabetic retinopathy to inform strategies to reduce the burden of type 2 diabetes complications.